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pentobarbital will lessen the extent or result of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or impact of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.pentobarbital will lessen the level or impact of levonorgestrel oral/ethinylest